Lipids and development of the human brain.
نویسنده
چکیده
concentration of plasma corticosterone rises at weaning, when fatty acid oxidation is falling. However, it is likely that the hepatic capacity for fatty acid oxidation is regulated by the interactions of both hormones and the diet. Neither fat feeding nor starvation of the mother had any effect on the foetal hepatic capacity for fatty acid oxidation, thus suggesting a requirement for another process as well as a dietary change for induction to occur at birth. An increase in 3-hydroxyacylCoA dehydrogenase activity takes place after caesarian delivery even though no milk is consumed. Thus it seems that the increase in the activity of this enzyme after birth does not require lipid ingestion as a stimulus, although a small amount of lipid is mobilized from body reserves at this time. Experiments at weaning indicate that the diet is a major factor in the control of 3-hydroxyacyl-CoA dehydrogenase activity, the capacity for palmitoylcarnitine oxidation, the blood ketone-body concentration and the activities of the enzymes of ketogenesis. Thus premature weaning on to a high-carbohydrate diet at day 18 after birth leads to a lower capacity for fatty acid oxidation and a lower blood ketone-body content at day 24, whereas weaning on to a high-fat-content diet at day 18 does not alter the normal fall in the capacity for fatty acid oxidation by day 24, but does decrease the normal fall in blood ketone-body content. Weaning on to a high-fat-content diet decreases the normal fall at weaning in 3-hydroxyacyl-CoA dehydrogenase activity, whereas premature weaning on to a high-carbohydrate-content diet causes an earlier decrease in the activity of the enzyme.
منابع مشابه
Editorial : Sustainable Development of Cognitive Science and Technology Ecosystem an Overview to the “Human Brain Project” as a Functioning Sample
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 4 2 شماره
صفحات -
تاریخ انتشار 1976